Basic Information
| LncRNA/CircRNA Name | HOTAIR |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | Cisplatin;etoposide;Adriamycin | |
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | small cell lung cancer |
| ICD-0-3 | C56.9 |
| Methods | qPCR, Western blot, etc. |
| Sample | CLC tissues, The human SCLC cell lines NCI-H69 and NCI-H446 and the multidrug-resistant subline NCI-H69AR |
| Expression Pattern | up-regulated |
| Function Description | EZH2 and H3K27me3 levels were markedly higher in SCLC tissues and multidrug-resistant SCLC cells. The results indicated that H3K27me3 was related to multidrug resistance. HOTAIR overexpression and knockdown showed that EZH2 and H3K27me3 were regulated by HOTAIR. Moreover, H3K27me3 affected HOXA1 DNA methylation levels. Strikingly, we found that H3K27me3 acted as a negative feedback regulator of HOTAIR. |
| Pubmed ID | 30596070 |
| Year | 2019 |
| Title | H3K27me3 induces multidrug resistance in small cell lung cancer by affecting HOXA1 DNA methylation via regulation of the lncRNA HOTAIR |
External Links
| Links for HOTAIR | GenBank HGNC NONCODE |
| Links for small cell lung cancer | OMIM COSMIC |