Basic Information
| LncRNA/CircRNA Name | HOTTIP |
| Synonyms | HOTTIP, HOXA-AS6, HOXA13-AS1, NCRNA00213 |
| Region | GRCh38_7:27198575-27207259 |
| Ensemble | ENSG00000243766 |
| Refseq | NR_037843 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | prostate cancer |
| ICD-0-3 | C61.9 |
| Methods | qPCR, Luciferase reporter assay, Western blot, etc. |
| Sample | PCa cell lines (DU145, PC-3, LNCaP, 22Rv1). PCa tissues and paired adjacent noncancerous tissues . |
| Expression Pattern | up-regulated |
| Function Description | Above all, knockdown of HOTTIP could represent a rational therapeutic strategy for PCa.Bioinformatics online programs predicted that HOTTIP sponge miR-216a-5p at 3'-UTR with complementary binding sites, which was validated using luciferase reporter assay. HOTTIP could negatively regulate the expression of miR-216a-5p in PCa cells. |
| Pubmed ID | 29884766 |
| Year | 2018 |
| Title | Long non-coding RNA HOTTIP promotes prostate cancer cells proliferation and migration by sponging miR-216a-5p. |
External Links
| Links for HOTTIP | GenBank HGNC NONCODE |
| Links for prostate cancer | OMIM COSMIC |