Basic Information
| LncRNA/CircRNA Name | HOTTIP |
| Synonyms | HOTTIP, HOXA-AS6, HOXA13-AS1, NCRNA00213 |
| Region | GRCh38_7:27198575-27207259 |
| Ensemble | ENSG00000243766 |
| Refseq | NR_037843 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | pancreatic cancer |
| ICD-0-3 | C25 |
| Methods | qPCR, Western blot, RIP |
| Sample | cell lines (PANC-1 and SW1990) |
| Expression Pattern | up-regulated |
| Function Description | HOTTIP was highly expressed in PCSCs.Patients with higher HOTTIP expression had shorter disease-free survival and overall survival than those with lower expression. HOTTIP alterations affected stemness, including sphericity, tumorigenesis, and stem factors (LIN28, NANOG, OCT4, and SOX2) and markers (ALDH1, CD44, and CD133).HOTTIP mediated HOXA9 to enhance the Wnt/B-catenin pathway by binding to WDR5 in PCSCs.HOTTIP or HOXA9 alterations influenced stemness.the HOTTIP/WDR5/HOXA9/Wnt axis contributes to PCSC stemness and is a potential therapeutic target for PDAC. |
| Pubmed ID | 28947139 |
| Year | 2017 |
| Title | LncRNA HOTTIP modulates cancer stem cell properties in human pancreatic cancer by regulating HOXA9. |
External Links
| Links for HOTTIP | GenBank HGNC NONCODE |
| Links for pancreatic cancer | OMIM COSMIC |