Basic Information
| LncRNA/CircRNA Name | HOTTIP |
| Synonyms | HOTTIP, HOXA-AS6, HOXA13-AS1, NCRNA00213 |
| Region | GRCh38_7:27198575-27207259 |
| Ensemble | ENSG00000243766 |
| Refseq | NR_037843 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | Paclitaxel | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | lung adenocarcinoma |
| ICD-0-3 | C34 |
| Methods | qPCR, Western blot |
| Sample | lung adenocarcinom tissue, cell lines (16HBE, A549, A549/PA) |
| Expression Pattern | up-regulated |
| Function Description | HOTTIP was overexpressed in lung adenocarcinoma and significantly increased in the treatment-insensitive group.Overexpression of HOTTIP, proliferation ability of A549 and drug resistance of A549/PA was significantly enhanced.HOTTIP can promote the progression of lung adenocarcinoma, and the formation of lung adenocarcinoma resistance regulated by the protein kinase B (AKT) signaling pathway. |
| Pubmed ID | 29272003 |
| Year | 2017 |
| Title | Overexpression of HOTTIP promotes proliferation and drug resistance of lung adenocarcinoma by regulating AKT signaling pathway. |
External Links
| Links for HOTTIP | GenBank HGNC NONCODE |
| Links for lung adenocarcinoma | OMIM COSMIC |