Basic Information
| LncRNA/CircRNA Name | HOTTIP |
| Synonyms | HOTTIP, HOXA-AS6, HOXA13-AS1, NCRNA00213 |
| Region | GRCh38_7:27198575-27207259 |
| Ensemble | ENSG00000243766 |
| Refseq | NR_037843 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | papillary thyroid cancer |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot, RIP etc. |
| Sample | Papillary thyroid carcinoma tissues, cell lines (TPC-1 and HTH83) |
| Expression Pattern | up-regulated |
| Function Description | HOTTIP was upregulated in human PTC tissues and PTC cell lines.In addition,HOTTIP knockdown inhibited the proliferation, invasion and migration in vitro together with in vivo tumorigenesis of PTC cells.Additionally, HOTTIP knockdown downregulated Akt1 expression and suppressed cell proliferation, invasion and migration in PTC cells by regulating miR-637. In contrast, miR-637 inhibitor reversed above-mentioned tendencies caused by HOTTIP knockdown. |
| Pubmed ID | 29474928 |
| Year | 2018 |
| Title | LncRNA HOTTIP promotes papillary thyroid carcinoma cell proliferation, invasion and migration by regulating miR-637. |
External Links
| Links for HOTTIP | GenBank HGNC NONCODE |
| Links for papillary thyroid cancer | OMIM COSMIC |