Basic Information
| LncRNA/CircRNA Name | HOTTIP |
| Synonyms | NA |
| Region | GRCh38_7:27198575-27207259 |
| Ensemble | ENSG00000243766 |
| Refseq | NR_037843 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | prostate cancer |
| ICD-0-3 | C61.9 |
| Methods | qRT-PCR etc. |
| Sample | prostate cancer tissues and non-neoplastic parenchyma , |
| Expression Pattern | up-regulated |
| Function Description | Increased HOTTIP expression was observed in all available prostate cancer tissue specimens compared with that in paired normal tissue.High HOTTIP expression was positively associated with bad clinicopathologic features, including higher pathologic T stage , presence of extraprostatic extension , seminal vesicle invasion , perineural invasion , and the tumor involvement of resection margin .In particular, significantly increased HOTTIP expression was observed in specimens from patients in the high or very high-risk group.Also, patients with high HOTTIP expression showed poorer overall survival than those with low expression. |
| Pubmed ID | 31570281 |
| Year | 2019 |
| Title | Long Noncoding RNA HOTTIP Overexpression: A Potential Prognostic Biomarker in Prostate Cancer |
External Links
| Links for HOTTIP | GenBank HGNC NONCODE |
| Links for prostate cancer | OMIM COSMIC |