Basic Information
| LncRNA/CircRNA Name | HOTTIP |
| Synonyms | HOXA transcript at the distal tip |
| Region | GRCh38_7:27198575-27207259 |
| Ensemble | ENSG00000243766 |
| Refseq | NR_037843 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | Cisplatin | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | Western blot, qRT-PCR, Dual Luciferase Reporter Assay, RIP |
| Sample | serum samples,GC cell lines (MGC-803 and MKN-45) |
| Expression Pattern | up-regulated |
| Function Description | HOTTIP level was upregulated in cisplatin-resistant GC cells and its downregulation enhanced cisplatin sensitivity.exosomal HOTTIP promoted cisplatin resistance via activating HMGA1 in GC cells.Clinically, high expression of exosomal HOTTIP in serum was associated with poor response to cisplatin treatment in GC patients. |
| Pubmed ID | 31908497 |
| Year | 2019 |
| Title | Exosome-Mediated Transfer of lncRNA HOTTIP Promotes Cisplatin Resistance in Gastric Cancer Cells by Regulating HMGA1/miR-218 Axis |
External Links
| Links for HOTTIP | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |