Basic Information
| LncRNA/CircRNA Name | HOTTIP |
| Synonyms | HOXA transcript at the distal tip |
| Region | GRCh38_7:27198575-27207259 |
| Ensemble | ENSG00000243766 |
| Refseq | NR_037843 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qRT-PCR, Western blotting Assay |
| Sample | tumors and noncancerous tissues,CRC cell lines (HCT116, LoVo, RKO, SW620, SW480, and HT29) ,colonic epithelial cell line HCoEpiC |
| Expression Pattern | up-regulated |
| Function Description | lncRNA HOTTIP Is Highly Expressed in CRC Samples.HOTTIP Regulates Cell Proliferation and Cell Cycle in CRC In Vitro.HOTTIP Regulates CRC Cell Invasion and EMT. |
| Pubmed ID | 31945724 |
| Year | 2020 |
| Title | The Long Non-coding RNA HOTTIP Is Highly Expressed in Colorectal Cancer and Enhances Cell Proliferation and Invasion |
External Links
| Links for HOTTIP | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |