Basic Information
| LncRNA/CircRNA Name | HOTTIP |
| Synonyms | NA |
| Region | GRCh38_7:27198575-27207259 |
| Ensemble | ENSG00000243766 |
| Refseq | NR_037843 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | Cisplatin | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | prostate cancer |
| ICD-0-3 | C61.9 |
| Methods | qPCR, Western blot |
| Sample | PCa tissues, cell lines |
| Expression Pattern | up-regulated |
| Function Description | In this study, we found that the HOTTIP mRNA levels were increased in the PCa patient samples and PCa cell lines compared with the controls. |
| Pubmed ID | 30809864 |
| Year | 2019 |
| Title | Knockdown of the long noncoding RNA HOTTIP inhibits cell proliferation and enhances cell sensitivity to cisplatin by suppressing the Wnt/?-catenin pathway in prostate cancer. |
External Links
| Links for HOTTIP | GenBank HGNC NONCODE |
| Links for prostate cancer | OMIM COSMIC |