Basic Information
| LncRNA/CircRNA Name | HOTTIP |
| Synonyms | NA |
| Region | GRCh38_7:27198575-27207259 |
| Ensemble | ENSG00000243766 |
| Refseq | NR_037843 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | papillary thyroid cancer |
| ICD-0-3 | NA |
| Methods | qPCR etc |
| Sample | PTC tissues,cell lines(IHH-4 and HTH-84) |
| Expression Pattern | up-regulated |
| Function Description | APAS was downregulated, while the lncRNA HOXA transcript at the distal tip (HOTTIP) was upregulated in patients with PTC.PAPAS is an upstream negative regulator of HOTTIP in PTC |
| Pubmed ID | 32194727 |
| Year | 2020 |
| Title | Long non-coding (lnc)RNA PAPAS overexpression inhibits tumor growth in papillary thyroid carcinoma by downregulating lncRNA HOTTIP |
External Links
| Links for HOTTIP | GenBank HGNC NONCODE |
| Links for papillary thyroid cancer | OMIM COSMIC |