Basic Information
| LncRNA/CircRNA Name | HOTTIP |
| Synonyms | NA |
| Region | GRCh38_7:27198575-27207259 |
| Ensemble | ENSG00000243766 |
| Refseq | NR_037843 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | Cisplatin | |
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | pancreatic cancer |
| ICD-0-3 | C25 |
| Methods | qPCR, Western blot, Luciferase reporter assay, RIP etc. |
| Sample | cell lines (PANC-1, HS766T, AsPC-1, HPDE6-C7) |
| Expression Pattern | up-regulated |
| Function Description | Rescue experiments showed that regulating miR-137 cannot affect the expression of HOTTIP, miR-137 is a downstream target of HOTTIP, and down-regulation of miR-137 expression can obviously hinder the cisplatin sensitization effect of silencing HOTTIP on cisplatin-resistant pancreatic cancer cells. |
| Pubmed ID | 32280243 |
| Year | 2020 |
| Title | LncRNA HOTTIP Participates in Cisplatin Resistance of Tumor Cells by Regulating miR-137 Expression in Pancreatic Cancer |
External Links
| Links for HOTTIP | GenBank HGNC NONCODE |
| Links for pancreatic cancer | OMIM COSMIC |