Basic Information
| LncRNA/CircRNA Name | HOTAIRM1 |
| Synonyms | HOTAIRM1, HOXA-AS1, HOXA1-AS1, NCRNA00179 |
| Region | GRCh38_7:27095647-27100265 |
| Ensemble | ENSG00000233429 |
| Refseq | NR_038366 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | acute promyelocytic leukemia |
| ICD-0-3 | NA |
| Methods | qPCR |
| Sample | cell line (HEK-293T) |
| Expression Pattern | down-regulated |
| Function Description | PU.1 directly activates the expression of HOTAIRM1 through binding to the regulatory region of HOTAIRM1 during granulocytic differentiation. The reduced PU.1 expression, rather than PML-RARa itself, results in the low expression of HOTAIRM1 in APL cells. |
| Pubmed ID | 27146823 |
| Year | 2016 |
| Title | PU.1 controls the expression of long noncoding RNA HOTAIRM1 during granulocytic differentiation |
External Links
| Links for HOTAIRM1 | GenBank HGNC NONCODE |
| Links for acute promyelocytic leukemia | OMIM COSMIC |