Basic Information
| LncRNA/CircRNA Name | HOTAIRM1 |
| Synonyms | HOXA transcript antisense RNA myeloid-specific 1 |
| Region | GRCh38_7:27095647-27100265 |
| Ensemble | ENSG00000233429 |
| Refseq | NR_038366 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | type I endometrial cancer |
| ICD-0-3 | NA |
| Methods | qRT-PCR, Western blot Assay |
| Sample | Tissue Sample,endometrioid adenocarcinoma cell lines, Ishikawa (highly differentiated) and HEC-1A (medium differentiated) |
| Expression Pattern | up-regulated |
| Function Description | The expression levels of HOTAIRM1 and HOXA1 were significantly upregulated in type I EC tissues. Furthermore, the expression of HOTAIRM1 and HOXA1 were both significantly correlated with International Federation of Gynecology and Obstetrics (FIGO) stage and lymph node metastasis. The expression of HOTAIRM1 was significantly correlated with that of HOXA1. Knockdown of HOTAIRM1 significantly inhibited cell proliferation, migration, invasion and epithelial-mesenchymal transition (EMT) in vitro, while the over-expression of HOTAIRM1 led to the opposite effects. Moreover, we identified that HOTAIRM1 acts as a regulator for the expression of the HOXA1 gene in type I EC cells. |
| Pubmed ID | 31853186 |
| Year | 2019 |
| Title | LncRNA HOTAIRM1/HOXA1 Axis Promotes Cell Proliferation, Migration And Invasion In Endometrial Cancer |
External Links
| Links for HOTAIRM1 | GenBank HGNC NONCODE |
| Links for type I endometrial cancer | OMIM COSMIC |