Basic Information
| LncRNA/CircRNA Name | HOTAIRM1 |
| Synonyms | HOX antisense intergenic RNA myeloid 1 |
| Region | GRCh38_7:27095647-27100265 |
| Ensemble | ENSG00000233429 |
| Refseq | NR_038366 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | acute myeloid leukemia |
| ICD-0-3 | NA |
| Methods | qRT-PCR, Western blot |
| Sample | AML cell lines HL60 and THP-1 |
| Expression Pattern | up-regulated |
| Function Description | knockdown of HOTAIRM1 enhanced Ara-C-induced reduction of cell viability and increase of cell apoptosis. HOTAIRM1 knockdown suppressed the glucose consumption and lactate production, as well as the expression of PFKP in AML cells. Besides, HOTAIRM1 knockdown resulted in a significant inhibitory effect on the Wnt/?-catenin pathway. |
| Pubmed ID | 31904363 |
| Year | 2020 |
| Title | HOTAIRM1 Knockdown Enhances Cytarabine-Induced Cytotoxicity by Suppression of Glycolysis Through the Wnt/?-catenin/PFKP Pathway in Acute Myeloid Leukemia Cells |
External Links
| Links for HOTAIRM1 | GenBank HGNC NONCODE |
| Links for acute myeloid leukemia | OMIM COSMIC |