Basic Information
| LncRNA/CircRNA Name | HOTAIRM1 |
| Synonyms | HOX antisense intergenic RNA myeloid 1 |
| Region | GRCh38_7:27095647-27100265 |
| Ensemble | ENSG00000233429 |
| Refseq | NR_038366 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | ovarian cancer |
| ICD-0-3 | C56.9 |
| Methods | qRT-PCR, Western blot, RIP, Luciferase activity assay |
| Sample | OC tissue samples,OC cell lines (SKOV3, OVCAR3, A2780 and ES-2) and normal human ovarian epithelial cell line (HOSEpiC) |
| Expression Pattern | down-regulated |
| Function Description | HOTAIRM1 expression was lowered in OC tumor tissues and cells. Decreased HOTAIRM1 expression was associated with advanced FIGO stages and lymphatic metastasis. Up-regulation of HOTAIRM1 suppressed OC cell proliferation and invasion, and promoted apoptosis. Also, HOTAIRM1 slowed OC tumor growth in vivo. Moreover, HOTAIRM1 could serve as a competing endogenous RNA (ceRNA) of miR-106a-5p to derepress ARHGAP24 expression. |
| Pubmed ID | 31935390 |
| Year | 2020 |
| Title | HOTAIRM1 Suppresses Cell Proliferation and Invasion in Ovarian Cancer Through Facilitating ARHGAP24 Expression by Sponging miR-106a-5p |
External Links
| Links for HOTAIRM1 | GenBank HGNC NONCODE |
| Links for ovarian cancer | OMIM COSMIC |