Basic Information
| LncRNA/CircRNA Name | HOTAIRM1 |
| Synonyms | NA |
| Region | GRCh38_7:27095647-27100265 |
| Ensemble | ENSG00000233429 |
| Refseq | NR_038366 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | head and neck cancer |
| ICD-0-3 | C76.0 |
| Methods | qPCR, Western blot, Luciferase reporter assay |
| Sample | head and neck tumor tissues, cell lines (NP69, Tca-8113, TU177 and HNE1) |
| Expression Pattern | down-regulated |
| Function Description | The expression level of HOTAIRM1 was downregulated in human HNT tissues and cells. Overexpression of HOTAIRM1 significantly moderated Fadu cells proliferation, apoptosis, migration, and invasion in vitro and impaired the tumorigenesis in vivo. The expression level of miR-148a was upregulated in human HNT tissue compared to the adjacent tissues. We identified that miR-148a was a target of HOTAIRM1 and its expression levels were reduced by HOTAIRM1. Transfection of miR-148a mimics increased proliferation, migration, and invasion of Fadu cells. DLGAP1 was identified as a novel target of miR-148a and its expression level was promoted by either HOTAIRM1 overexpression or miR-148a knockdown. Overexpression of DLGAP1 also facilitated the cell viability and metastasis of Fadu cells. |
| Pubmed ID | 29905017 |
| Year | 2018 |
| Title | HOTAIRM1 Competed Endogenously With miR-148a to Regulate DLGAP1 in Head and Neck Tumor Cells |
External Links
| Links for HOTAIRM1 | GenBank HGNC NONCODE |
| Links for head and neck cancer | OMIM COSMIC |