Basic Information
| LncRNA/CircRNA Name | HOTAIR |
| Synonyms | HOTAIR, HOXAS, HOXC-AS4, HOXC11-AS1, NCRNA00072 |
| Region | GRCh38_12:53962308-53974956 |
| Ensemble | ENSG00000228630 |
| Refseq | NR_003716 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | liver cancer |
| ICD-0-3 | C22.0 |
| Methods | qPCR, western blot etc. |
| Sample | Liver cancer tissues, cell lines (MHCC 97H, HepG2 and Hep3B) |
| Expression Pattern | up-regulated |
| Function Description | It was demonstrated that the expression of HOTAIR was upregulated in liver cancer tissues and 3 liver cancer cell lines (MHCC97H, HepG2 and Hep3B). Overall, HOTAIR contributes to the proliferation and growth of liver cancer via downregulation of miR-217. |
| Pubmed ID | 29849802 |
| Year | 2018 |
| Title | HOTAIR contributes to the growth of liver cancer via targeting miR-217 |
External Links
| Links for HOTAIR | GenBank HGNC NONCODE |
| Links for liver cancer | OMIM COSMIC |