Basic Information
| LncRNA/CircRNA Name | HOTAIR |
| Synonyms | HOTAIR, HOXAS, HOXC-AS4, HOXC11-AS1, NCRNA00072 |
| Region | GRCh38_12:53962308-53974956 |
| Ensemble | ENSG00000228630 |
| Refseq | NR_003716 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qPCR, Western blot, Luciferase reporter assay etc. |
| Sample | hepatocellular carcinoma tissues, cell lines (Huh7, Hep3B, HepG2, MHCC97H) |
| Expression Pattern | up-regulated |
| Function Description | Our data showed that HOTAIR was overexpressed in HCC tissues and cell lines. Taken together, our study demonstrated that the HOTAIR-miR-23b-3p-ZEB1 axis may provide a new perspective for treatment of HCC. |
| Pubmed ID | 29778425 |
| Year | 2018 |
| Title | LncRNA HOTAIR contributes to the malignancy of hepatocellular carcinoma by enhancing epithelial-mesenchymal transition via sponging miR-23b-3p from ZEB1. |
External Links
| Links for HOTAIR | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |