Basic Information
| LncRNA/CircRNA Name | AB209371 |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | ovarian cancer |
| ICD-0-3 | C56.9 |
| Methods | qRT-PCR , Western blot etc. |
| Sample | non-tumor ovarian and OC tissues?, human OC cell line (UWB1.289) |
| Expression Pattern | up-regulated |
| Function Description | AB209371 gene and Survivin gene were up-regulated in OC and positively correlated with OC development. AB209371 over-expression led to up-regulated Survivin in OC cells.AB209371 over-expression led to down-regulated miR-203. However, miR-203 over-expression failed to affect AB209371, but down-regulated the expression of Survivin.Over-expressions of AB209371 and Survivin resulted in the increased proliferation rate of OC cells. Over-expression MiR-203 played the opposite role and attenuated the effects of AB209371 over-expression. Therefore, AB209371 may down-regulate miR-203 to up-regulate Survivin, thereby promoting OC cell proliferation. |
| Pubmed ID | 31601255 |
| Year | 2019 |
| Title | LncRNA AB209371 Up-Regulated Survivin Gene by Down-Regulating miR-203 in Ovarian Carcinoma |
External Links
| Links for AB209371 | GenBank HGNC NONCODE |
| Links for ovarian cancer | OMIM COSMIC |