Basic Information
| LncRNA/CircRNA Name | HOTAIR |
| Synonyms | HOTAIR, HOXAS, HOXC-AS4, HOXC11-AS1, NCRNA00072 |
| Region | GRCh38_12:53962308-53974956 |
| Ensemble | ENSG00000228630 |
| Refseq | NR_003716 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | cervical cancer |
| ICD-0-3 | C53 |
| Methods | qPCR, Luciferase reporter assay etc. |
| Sample | osteosarcoma tissues, cell lines (MNNG and U3OS) |
| Expression Pattern | down-regulated |
| Function Description | We found that rs2366152C was over-represented in low HOTAIR expressing HPV positive cervical cancer cases compared to HPV negative controls. We assessed the HOTAIR expression levels among samples genotyped for rs2366152C and found that the expression was significantly reduced in the C allele positive samples compared to the C allele negative samples, exclusively among the LH CaCx cases. |
| Pubmed ID | 27683269 |
| Year | 2016 |
| Title | Identification of genetic variation in the lncRNA HOTAIR associated with HPV16-related cervical cancer pathogenesis. |
External Links
| Links for HOTAIR | GenBank HGNC NONCODE |
| Links for cervical cancer | OMIM COSMIC |