Basic Information
| LncRNA/CircRNA Name | HOTAIR |
| Synonyms | HOTAIR, HOXAS, HOXC-AS4, HOXC11-AS1, NCRNA00072 |
| Region | GRCh38_12:53962308-53974956 |
| Ensemble | ENSG00000228630 |
| Refseq | NR_003716 |
| Regulatory Mechanism | Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Information of Cancer
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR, ChIP etc. |
| Sample | cell lines (SUZ12, EZH2, PRC2 etc.) |
| Expression Pattern | up-regulated |
| Function Description | Quantitative PCR showed that HOTAIR is overexpressed from hundreds to nearly two thousand- fold in breast cancer metastases, and HOTAIR level is sometimes high but heterogeneous among primary tumors . We next measured HOTAIR level in an independent panel of 132 primary breast tumors (stage I and II) with extensive clinical follow-up13. Indeed, nearly one third of primary breast tumors overexpress HOTAIR by over 125-fold over normal breast epithelia, the minimum level of HOTAIR overexpression observed in bona fide metastases, and high HOTAIR level is a significant predictor of subsequent metastasis and death. |
| Pubmed ID | 20393566 |
| Year | 2010 |
| Title | Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis. |
External Links
| Links for HOTAIR | GenBank HGNC Noncode |
| Links for breast cancer | Omim Cosmic |