Basic Information
| LncRNA/CircRNA Name | HOTAIR |
| Synonyms | HOTAIR, HOXAS, HOXC-AS4, HOXC11-AS1, NCRNA00072 |
| Region | GRCh38_12:53962308-53974956 |
| Ensemble | ENSG00000228630 |
| Refseq | NR_003716 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | cervical cancer |
| ICD-0-3 | C53 |
| Methods | qPCR, Western blot, RNAi etc |
| Sample | cervical cancer tissues, cell lines (MRI-H196 and MRI-H186) |
| Expression Pattern | down-regulated |
| Function Description | NRP2 was identified as a virtual target gene of miR-331-3p with a binding site of miR-331-3p,and HOTAIR was directly sponged to miR-331-3p,miR-331-3p reduced luciferase activity of wild-type of NRP2 3'UTR and HOTAIR, but not those of mutant NRP2 3'UTR and HOTAIR.MiR-331-3p down-regulated NRP2 and E7 expression levels,and further promoted cell apoptosis,while inhibited cell proliferation.Cell transfected with HPV16 E7 displayed lower levels of HOTAIR,NRP2 and P53,a higher level of miR-331-3p,over-expression of E7 further repressed cell apoptosis,while improved cell proliferation compared with control. Normal HPV (+) group exhibited a higher miR-331-3p, and lower mRNA levels of HOTAIR and NRP2 than HPV (-) group. |
| Pubmed ID | 29130509 |
| Year | 2018 |
| Title | ARFHPV E7 oncogene, lncRNA HOTAIR, miR-331-3p and its target, NRP2, form a negative feedback loop to regulate the apoptosis in the tumorigenesis in HPV positive cervical cancer. |
External Links
| Links for HOTAIR | GenBank HGNC NONCODE |
| Links for cervical cancer | OMIM COSMIC |