Basic Information
| LncRNA/CircRNA Name | HOTAIR |
| Synonyms | HOTAIR, HOXAS, HOXC-AS4, HOXC11-AS1, NCRNA00072 |
| Region | GRCh38_12:53962308-53974956 |
| Ensemble | ENSG00000228630 |
| Refseq | NR_003716 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | Microarray, qPCR etc. |
| Sample | gastric cancer tissues, cell lines (HCG-27, SGC-7901) |
| Expression Pattern | up-regulated |
| Function Description | H19 and HOTAIR displayed significantly higher levels and the up-regulation of HOTAIR was associated with lymphatic metastasis and poor differentiation. |
| Pubmed ID | 26237576 |
| Year | 2015 |
| Title | Long non-coding RNA Linc00152 is involved in cell cycle arrest, apoptosis, epithelial to mesenchymal transition, cell migration and invasion in gastric cancer. |
External Links
| Links for HOTAIR | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |