Basic Information
| LncRNA/CircRNA Name | HOTAIR |
| Synonyms | HOTAIR, HOXAS, HOXC-AS4, HOXC11-AS1, NCRNA00072 |
| Region | GRCh38_12:53962308-53974956 |
| Ensemble | ENSG00000228630 |
| Refseq | NR_003716 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR, Western blot, in vitro knockdown, RIP |
| Sample | gastric cancer tissues, gastric cancer cell lines (AGS, MKN28, MKN45, BGC823, HGC27, MGC803 and SGC7901) |
| Expression Pattern | up-regulated |
| Function Description | HOTAIR was bound to Runx3 protein and identified the fragment of HOTAIR spanning 1951-2100-bp as the specific binding site. In addition, mex-3 RNA binding family member B (Mex3b) was an E3 ligase involved in HOTAIR-induced ubiquitous degradation of Runx3. Silencing the expression of HOTAIR or Mex3b attenuated the degradation of Runx3. Inhibition of HOTAIR significantly suppressed gastric cancer cell migration and invasion through upregulating claudin1, which could be reversed by co-deficiency of Runx3. The expression of Runx3 was regulated by several mechanisms including promoter methylation, histone acetylation, miRNAs, etc. |
| Pubmed ID | 29417297 |
| Year | 2018 |
| Title | HOTAIR induces the ubiquitination of Runx3 by interacting with Mex3b and enhances the invasion of gastric cancer cells. |
External Links
| Links for HOTAIR | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |