Basic Information
| LncRNA/CircRNA Name | AKR7L |
| Synonyms | AKR7L, AFAR3, AFB1-AR 3, AFB1-AR3, AKR7A4 |
| Region | GRCh38_1:19265982-19274194 |
| Ensemble | ENSG00000211454 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | Microarray, qPCR, RNAi etc. |
| Sample | gastric cancer tissues |
| Expression Pattern | down-regulated |
| Function Description | LncRNA M59227 and 3 mRNAs, PLK1, PTTG1 and VCAN, were overexpressed in GC. In contrast, the expression of 4 lncRNAs, LOC150622, AKR7 L, DQ192290 and BC040587, and 2 mRNAs, DRD5 and GDF5, were downregulated in GC.The results indicated that TUSC7 is a p53-regulated tumour suppressor that acts in part by repressing miR-23b and that TUSC7 may be a key regulatory hub in GC. |
| Pubmed ID | 25765901 |
| Year | 2015 |
| Title | Reciprocal repression between TUSC7 and miR-23b in gastric cancer. |
External Links
| Links for AKR7L | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |