Basic Information
| LncRNA/CircRNA Name | HOTAIR |
| Synonyms | HOTAIR, HOXAS, HOXC-AS4, HOXC11-AS1, NCRNA00072 |
| Region | GRCh38_12:53962308-53974956 |
| Ensemble | ENSG00000228630 |
| Refseq | NR_003716 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | 5-fluorouracil (5-FU) and Cisplatin | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR |
| Sample | gastric cancer tissues, cell lines (BGC-823 and MKN-45) |
| Expression Pattern | up-regulated |
| Function Description | lncRNA HOTAIR had an extremely high expression level in GC cells, and predicted poor prognosis in patients.Down-regulation of HOTAIR could promote chemosensitivity, induce apoptosis of GC cells, and significantly inhibit GC cell proliferation, invasion and metastasis in vivo and in vitro. |
| Pubmed ID | 29236333 |
| Year | 2017 |
| Title | Effect and mechanism of lncRNA HOTAIR on occurrence and development of gastric cancer. |
External Links
| Links for HOTAIR | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |