Basic Information
| LncRNA/CircRNA Name | HOTAIR |
| Synonyms | HOTAIR, HOXAS, HOXC-AS4, HOXC11-AS1, NCRNA00072 |
| Region | GRCh38_12:53962308-53974956 |
| Ensemble | ENSG00000228630 |
| Refseq | NR_003716 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | estradiol | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR, RNAi, ChIP, Dual luciferase reporter assay etc. |
| Sample | cell line (MCF7) |
| Expression Pattern | up-regulated |
| Function Description | Microscopic analysis showed that HOTAIR knockdown has suppressed the growth of MCF7 cells in comparison to the control or scramble-antisense treated cells even at 24 h of post HOTAIR siSENSE transfection. Growth analysis showed that HOTAIR knockdown has suppressed the growth of MCF7 cells significantly in comparison to the control (untreated) or scramble-antisense treated cells. |
| Pubmed ID | 23375982 |
| Year | 2013 |
| Title | Antisense transcript long noncoding RNA (lncRNA) HOTAIR is transcriptionally induced by estradiol. |
External Links
| Links for HOTAIR | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |