Basic Information
| LncRNA/CircRNA Name | HOTAIR |
| Synonyms | HOTAIR, HOXAS, HOXC-AS4, HOXC11-AS1, NCRNA00072 |
| Region | GRCh38_12:53962308-53974956 |
| Ensemble | ENSG00000228630 |
| Refseq | NR_003716 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR, Western blot, CHIP-PCR, Dual luciferase reporter assay etc. |
| Sample | cell lines (MDA-MB-231 and MCF-7) |
| Expression Pattern | up-regulated |
| Function Description | To explore why miR-7 expression was downregulated in breast cancer cells and BCSCs, we examined HOTAIR expression and found that the downregulation of miR-7 was closely related to the high level of HOTAIR expression in breast cancer patients. HOTAIR inhibits many tumor suppression genes including HoxD10 in MDA-MB-231 cells. We downregulated the expression of HOTAIR by RNA interference in MDA-MB-231 cells and found that the expression of HoxD10 along with miR-7 were enhanced. |
| Pubmed ID | 25070049 |
| Year | 2014 |
| Title | MiR-7, inhibited indirectly by lincRNA HOTAIR, directly inhibits SETDB1 and reverses the EMT of breast cancer stem cells by downregulating the STAT3 pathway. |
External Links
| Links for HOTAIR | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |