Basic Information
| LncRNA/CircRNA Name | HOTAIR |
| Synonyms | HOTAIR, HOXAS, HOXC-AS4, HOXC11-AS1, NCRNA00072 |
| Region | GRCh38_12:53962308-53974956 |
| Ensemble | ENSG00000228630 |
| Refseq | NR_003716 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | ovarian cancer |
| ICD-0-3 | C56.9 |
| Methods | qPCR, RNAi, Western blot, MTT assay etc. |
| Sample | ovarian cancer tissues, cell lines (A2780, 3AO, OVCAR3, SKOV3, HO-8910) |
| Expression Pattern | up-regulated |
| Function Description | HOTAIR overexpression promoted cell cycle progression (and thus cell proliferation) by activating the Wnt/B-Catenin signaling pathway. Likewise, knockdown of HOTAIR suppressed cell proliferation and arrested cell cycle at G1 phase via inhibition of Wnt/B-Catenin signaling. Moreover, the results of primary culture demonstrated that elevated HOTAIR expression correlated positively with chemoresistance in ovarian cancer. |
| Pubmed ID | 26341496 |
| Year | 2015 |
| Title | Overexpression of long non-coding RNA HOTAIR leads to chemoresistance by activating the Wnt/B-Catenin pathway in human ovarian cancer. |
External Links
| Links for HOTAIR | GenBank HGNC NONCODE |
| Links for ovarian cancer | OMIM COSMIC |