Basic Information
| LncRNA/CircRNA Name | HOTAIR |
| Synonyms | HOTAIR, HOXAS, HOXC-AS4, HOXC11-AS1, NCRNA00072 |
| Region | GRCh38_12:53962308-53974956 |
| Ensemble | ENSG00000228630 |
| Refseq | NR_003716 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | cervical cancer |
| ICD-0-3 | C53 |
| Methods | qPCR, Western blot, Luciferase Reporter Assay |
| Sample | cervical cancer cell lines (HeLa, CaSki, Me180, C-33A) |
| Expression Pattern | differential expression |
| Function Description | Finally, the in vivo experiment revealed that tumor growth and metastasis could also be inhibited by HOTAIR shRNA. Our present study elucidated the regulating role of HOTAIR/miR-326 axis in cervical cancer progression and provided a new potential therapeutic strategy for cervical cancer. Although many therapeutic means such as surgery, chemotherapy, radiotherapy have been applied to cervical treatment, the prognosis and the five-year survival rate are still not satisfactory4. Previous researches had shown that HOTAIR took part in forming a complex with Polycomb repressive complex 2 (PRC2) which finally result in histone H3 lysine methylation, cancer invasion and metastasis29-31. |
| Pubmed ID | 28893349 |
| Year | 2017 |
| Title | LncRNA-HOTAIR Activates Tumor Cell Proliferation and Migration by Suppressing MiR-326 in Cervical Cancer. |
External Links
| Links for HOTAIR | GenBank HGNC NONCODE |
| Links for cervical cancer | OMIM COSMIC |