Basic Information
| LncRNA/CircRNA Name | HOTAIR |
| Synonyms | HOTAIR, HOXAS, HOXC-AS4, HOXC11-AS1, NCRNA00072 |
| Region | GRCh38_12:53962308-53974956 |
| Ensemble | ENSG00000228630 |
| Refseq | NR_003716 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | cervical cancer |
| ICD-0-3 | C53 |
| Methods | qPCR, RNAi, Cell proliferation assay, Cell invasion assay etc. |
| Sample | cell line (HeLa) |
| Expression Pattern | up-regulated |
| Function Description | Here, we used quantitative real-time PCR (qRT-PCR) to detect the relative abundance of HOTAIR in different cell lines, HeLa cells showing the highest levels of HOTAIR expression. Quantitative analysis indicated that the percentage of apoptotic cells was significantly higher for siHOTAIR-transfected cells than for siNC-transfected cells. We next examined the effect of HOTAIR knockdown on the cell cycle. The percentage of cells in G1 phase was reduced whereas that in S phase and G2/M phase increased. At the same time, cell growth was significantly suppressed relative to the negative control siNC group (Fig. 1E). |
| Pubmed ID | 25762744 |
| Year | 2015 |
| Title | Quantitative Proteomics Analysis Reveals Novel Insights into Mechanisms of Action of Long Noncoding RNA Hox Transcript Antisense Intergenic RNA (HOTAIR) in HeLa Cells. |
External Links
| Links for HOTAIR | GenBank HGNC NONCODE |
| Links for cervical cancer | OMIM COSMIC |