Basic Information
| LncRNA/CircRNA Name | HOTAIR |
| Synonyms | HOTAIR, HOXAS, HOXC-AS4, HOXC11-AS1, NCRNA00072 |
| Region | GRCh38_12:53962308-53974956 |
| Ensemble | ENSG00000228630 |
| Refseq | NR_003716 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | cervical cancer |
| ICD-0-3 | C53 |
| Methods | qPCR, ELISA etc. |
| Sample | cervical cancer tissues |
| Expression Pattern | up-regulated |
| Function Description | We analyzed exosomal lncRNA levels in a cohort consisting of 30 cervical cancer patients, 30 cancer-free HPV-positive subjects and 30 HPV-negative normal subjects by qRT-PCR. The results indicated that the expression of exosomal HOTAIR and MALAT1 in cervicovaginal lavage samples of the cervical cancer patients was significantly higher than that of the HPV-positive subjects and HPV-negative cancer-free subject. The exosomal MEG-3 level in cervicovaginal lavage specimens of the cervical cancer patients was significantly lower than those of the HPV-positive subjects and HPV-negative cancer-free subjects. |
| Pubmed ID | 27184657 |
| Year | 2016 |
| Title | Exosomal Long Noncoding RNAs are Differentially Expressed in the Cervicovaginal Lavage Samples of Cervical Cancer Patients. |
External Links
| Links for HOTAIR | GenBank HGNC NONCODE |
| Links for cervical cancer | OMIM COSMIC |