Basic Information
| LncRNA/CircRNA Name | HOTAIR |
| Synonyms | HOTAIR, HOXAS, HOXC-AS4, HOXC11-AS1, NCRNA00072 |
| Region | GRCh38_12:53962308-53974956 |
| Ensemble | ENSG00000228630 |
| Refseq | NR_003716 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, RIP, Western blot etc. |
| Sample | colorectal cancer tissues, colorectal cancer cell lines ( HT29, SW480, FHC) |
| Expression Pattern | down-regulated |
| Function Description | HOTAIR contributes to 5FU resistance through suppressing miR-218 and activating NF-kB signaling in CRC. HOTAIR was reported to act as a prognostic circulating marker and potential therapeutic target in patients with tumor diseases,while its chemotherapeutic value has rarely been discussed in clinical research. Previous research has found that HOTAIR negatively regulated the expression of miRNAs mainly by functioning as a competing endogenous RNA (ceRNA) sponge, such as miR-145 and miR-331-3p in breast and gastric cancer, respectively. |
| Pubmed ID | 28918035 |
| Year | 2017 |
| Title | lncRNA HOTAIR Contributes to 5FU Resistance through Suppressing miR-218 and Activating NF-kB/TS Signaling in Colorectal Cancer. |
External Links
| Links for HOTAIR | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |