Basic Information
| LncRNA/CircRNA Name | HOTAIR |
| Synonyms | HOTAIR, HOXAS, HOXC-AS4, HOXC11-AS1, NCRNA00072 |
| Region | GRCh38_12:53962308-53974956 |
| Ensemble | ENSG00000228630 |
| Refseq | NR_003716 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | esophageal squamous cell carcinoma |
| ICD-0-3 | NA |
| Methods | qPCR, RNAi etc. |
| Sample | ESCC tissues, cell lines (KYSE30, KYSE150, KYSE450, KYSE510, KYSE180 etc.) |
| Expression Pattern | up-regulated |
| Function Description | Notably elevated HOTAIR expression levels were observed in cancerous tissues compared to adjacent noncancerous tissues, showing a high correlation with cancer metastasis, elevated TNM stage classification, and lowered overall survival rates. Multivariate analysis revealed that HOTAIR expression is also an independent prognostic factor for comparison of TNM stage and lymph node metastasis. |
| Pubmed ID | 24151120 |
| Year | 2013 |
| Title | Upregulation of the long non-coding RNA HOTAIR promotes esophageal squamous cell carcinoma metastasis and poor prognosis. |
External Links
| Links for HOTAIR | GenBank HGNC NONCODE |
| Links for esophageal squamous cell carcinoma | OMIM COSMIC |