Basic Information
| LncRNA/CircRNA Name | HOTAIR |
| Synonyms | HOTAIR, HOXAS, HOXC-AS4, HOXC11-AS1, NCRNA00072 |
| Region | GRCh38_12:53962308-53974956 |
| Ensemble | ENSG00000228630 |
| Refseq | NR_003716 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qPCR, Western blot, in vitro knockdown etc. |
| Sample | cell line (Bel7402) |
| Expression Pattern | up-regulated |
| Function Description | The HOTAIR gene was significantly overexpressed in HCC tissues compared with adjacent non-tumour tissues. Patients with high HOTAIR gene expression in their tumours had an increased risk of recurrence after hepatectomy. There was also a significant correlation between HOTAIR expression and lymph node metastasis. HOTAIR lincRNA might be a potential biomarker for the existence of lymph node metastasis in HCC. |
| Pubmed ID | 22289527 |
| Year | 2011 |
| Title | Large intervening non-coding RNA HOTAIR is associated with hepatocellular carcinoma progression. |
External Links
| Links for HOTAIR | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |