Basic Information
| LncRNA/CircRNA Name | HOTAIR |
| Synonyms | HOTAIR, HOXAS, HOXC-AS4, HOXC11-AS1, NCRNA00072 |
| Region | GRCh38_12:53962308-53974956 |
| Ensemble | ENSG00000228630 |
| Refseq | NR_003716 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | EGFR-TKIs | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | Microarray, qPCR, Cell proliferation assay etc. |
| Sample | cell lines (PC9, H1975, H1299 and A549) |
| Expression Pattern | down-regulated |
| Function Description | Overexpression of H19 and BC200 were observed in gefitinib-resistant lung cancer cell lines (PC9/R, A549, H1299 and H1975). However, in the gefitinib-sensitive cell line (PC9), MALAT1 and HOTAIR were downregulated. |
| Pubmed ID | 25482516 |
| Year | 2015 |
| Title | Microarray expression profile of long non-coding RNAs in EGFR-TKIs resistance of human non-small cell lung cancer. |
External Links
| Links for HOTAIR | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |