Basic Information
| LncRNA/CircRNA Name | HOTAIR |
| Synonyms | HOTAIR, HOXAS, HOXC-AS4, HOXC11-AS1, NCRNA00072 |
| Region | GRCh38_12:53962308-53974956 |
| Ensemble | ENSG00000228630 |
| Refseq | NR_003716 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | renal cell carcinoma |
| ICD-0-3 | C64.9 |
| Methods | Microarray, qPCR, Western blot, RNAi etc. |
| Sample | normal renal tissues, renal cell carcinoma cell lines (ACHN, A498, Caki-1) |
| Expression Pattern | up-regulated |
| Function Description | IGFBP2 and HOTAIR were co-expressed in clinical RCC samples. Our findings suggest that the HOTAIR-IGFBP2 axis plays critical roles in RCC metastasis and may serve as a novel therapeutic target for advanced RCC.Next, we analyzed the relationship between HOTAIR expression and patient prognosis using the Kaplan-Meier method. HOTAIR expression was significantly associated with a shorter survival in RCC patients |
| Pubmed ID | 28931862 |
| Year | 2017 |
| Title | Long non-coding RNA HOTAIR promotes cell migration by upregulating insulin growth factor-binding protein 2 in renal cell carcinoma. |
External Links
| Links for HOTAIR | GenBank HGNC NONCODE |
| Links for renal cell carcinoma | OMIM COSMIC |