Basic Information
| LncRNA/CircRNA Name | HOTAIR |
| Synonyms | HOTAIR, HOXAS, HOXC-AS4, HOXC11-AS1, NCRNA00072 |
| Region | GRCh38_12:53962308-53974956 |
| Ensemble | ENSG00000228630 |
| Refseq | NR_003716 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioma |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot etc. |
| Sample | cell lines (U-87 MG) |
| Expression Pattern | down-regulated |
| Function Description | The present study further demonstrated that miR-15b, HOTAIR, and p53 formed a mutually regulated loop. MiR-15b upregulated the expression of p53 but inhibited the expression of HOTAIR.In addition,miR-15b was able to regulate the expression of HOTAIR through p53.Furthermore,the examination of cell proliferation,apoptosis,and invasion revealed that both miR-15b and p53 inhibited the proliferation and invasion,but promoted the apoptosis,of glioma cells. In contrast,HOTAIR exerted effects that were the opposite of those exerted by miR-15b and p53 on glioma cells.The upregulation of HOTAIR suppressed the inhibitory effects of miR-15b and p53 on cell proliferation and invasion as well as the promoting effect of miR-15b and p53 on apoptosis. |
| Pubmed ID | 29323737 |
| Year | 2018 |
| Title | MiR-15b/HOTAIR/p53 form a regulatory loop that affects the growth of glioma cells. |
External Links
| Links for HOTAIR | GenBank HGNC NONCODE |
| Links for glioma | OMIM COSMIC |