Basic Information
| LncRNA/CircRNA Name | HOTAIR |
| Synonyms | HOTAIR, HOXAS, HOXC-AS4, HOXC11-AS1, NCRNA00072 |
| Region | GRCh38_12:53962308-53974956 |
| Ensemble | ENSG00000228630 |
| Refseq | NR_003716 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR etc. |
| Sample | lung cancer tissues, cell lines (A549, mK-ras-LE etc.) |
| Expression Pattern | up-regulated |
| Function Description | In the current study, we demonstrate that the tumor-promoting lincRNA HOTAIR is induced by Col-1 and its expression inversely correlates with acinar morphogenesis, a differentiation feature of lung epithelial cells in rBM 3-D culture. These in vitro findings suggest that the elevated HOTAIR expression in tumor tissues results from cancer cells' response to Col-1 that is aberrantly enriched in the tumor microenvironment. Our findings indicate that tumor-promoting Col-1 up-regulates the expression of HOTAIR in NSCLC cells. These initial results warrant further investigation of HOTAIR and other lincRNA genes in lung tumorigenesis. |
| Pubmed ID | 23668363 |
| Year | 2013 |
| Title | Induction of long intergenic non-coding RNA HOTAIR in lung cancer cells by type I collagen. |
External Links
| Links for HOTAIR | GenBank HGNC NONCODE |
| Links for lung cancer | OMIM COSMIC |