Basic Information
| LncRNA/CircRNA Name | HOTAIR |
| Synonyms | HOTAIR, HOXAS, HOXC-AS4, HOXC11-AS1, NCRNA00072 |
| Region | GRCh38_12:53962308-53974956 |
| Ensemble | ENSG00000228630 |
| Refseq | NR_003716 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | Cisplatin | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | lung adenocarcinoma |
| ICD-0-3 | C34 |
| Methods | qPCR, RNAi, Western blot, Luciferase reporter assay, MTT assay etc. |
| Sample | LAD tissues, cell line (A549/CDDP) |
| Expression Pattern | up-regulated |
| Function Description | Our results showed that HOTAIR was significantly upregulated in A549/CDDP cells compared with parental A549 cells. The results showed that si-HOTAIR increased miR-326 expression (Fig. 6b) and synergistically reduced SP1 expression (Fig. 6c), ultimately enhanced sensitivity to cisplatin in A549/CDDP cells. In contrast to si-HOTAIR, pcDNA/HOTAIR vector inhibited miR-326 expression and synergistically enhanced SP1 expression in A549 cells |
| Pubmed ID | 27460077 |
| Year | 2016 |
| Title | miR-326 reverses chemoresistance in human lung adenocarcinoma cells by targeting specificity protein 1. |
External Links
| Links for HOTAIR | GenBank HGNC NONCODE |
| Links for lung adenocarcinoma | OMIM COSMIC |