Basic Information
| LncRNA/CircRNA Name | HOTAIR |
| Synonyms | HOTAIR, HOXAS, HOXC-AS4, HOXC11-AS1, NCRNA00072 |
| Region | GRCh38_12:53962308-53974956 |
| Ensemble | ENSG00000228630 |
| Refseq | NR_003716 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | papillary thyroid cancer |
| ICD-0-3 | NA |
| Methods | qPCR, RNAi, Cell proliferation assay etc. |
| Sample | PTC tissues, cell line (HEK293) |
| Expression Pattern | up-regulated |
| Function Description | By detecting HOTAIR RNA expression in sixty paired PTC and normal tissues, we found higher expression of HOTAIR in PTC tissues compared to normal tissues. In BCPAP or HEK293 cells, ectopic expression of lncRNA HOTAIR significantly promoted cell proliferation. On the contrary, depletion of endogenous HOTAIR expression significantly suppresses PTC cell proliferation. |
| Pubmed ID | 27549736 |
| Year | 2016 |
| Title | Onco-lncRNA HOTAIR and its functional genetic variants in papillary thyroid carcinoma. |
External Links
| Links for HOTAIR | GenBank HGNC NONCODE |
| Links for papillary thyroid cancer | OMIM COSMIC |