Basic Information
| LncRNA/CircRNA Name | HOTAIR |
| Synonyms | HOTAIR, HOXAS, HOXC-AS4, HOXC11-AS1, NCRNA00072 |
| Region | GRCh38_12:53962308-53974956 |
| Ensemble | ENSG00000228630 |
| Refseq | NR_003716 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | Silibinin | |
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | bladder cancer |
| ICD-0-3 | C67 |
| Methods | Western blot, qPCR, ChIP |
| Sample | cell lines (T24, UM-UC-3) |
| Expression Pattern | up-regulated |
| Function Description | Silibinin was found to significantly decrease the expression levels of oncogenic HOTAIR and ZFAS |
| Pubmed ID | 29190895 |
| Year | 2017 |
| Title | Silibinin suppresses bladder cancer through down-regulation of actin cytoskeleton and PI3K/Akt signaling pathways |
External Links
| Links for HOTAIR | GenBank HGNC NONCODE |
| Links for bladder cancer | OMIM COSMIC |