Basic Information
| LncRNA/CircRNA Name | AK124454 |
| Synonyms | LOC105372310 |
| Region | GRCh38_19:20220597-20222169 |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | Microarray, qPCR, RNAi, Cell proliferation assay, Cell invasion assay etc. |
| Sample | breast cancer tissues, cell lines (MDA-MB-231, BT549, Hs578T and 293T) |
| Expression Pattern | up-regulated |
| Function Description | lncRNAs HIF1A-AS2 and AK124454 could promote cell proliferation and invasion, and attenuate G2-M arrest, which might contribute to paclitaxel resistance in TNBC cells. |
| Pubmed ID | 26921339 |
| Year | 2016 |
| Title | Transcriptome Analysis of Triple-Negative Breast Cancer Reveals an Integrated mRNA-lncRNA Signature with Predictive and Prognostic Value. |
External Links
| Links for AK124454 | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |