Basic Information
| LncRNA/CircRNA Name | HOTAIR |
| Synonyms | HOTAIR, HOXAS, HOXC-AS4, HOXC11-AS1, NCRNA00072 |
| Region | GRCh38_12:53962308-53974956 |
| Ensemble | ENSG00000228630 |
| Refseq | NR_003716 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | endometrial cancer |
| ICD-0-3 | NA |
| Methods | qPCR etc. |
| Sample | endometrial carcinoma tissues |
| Expression Pattern | up-regulated |
| Function Description | Our results revealed that HOTAIR expression in the EC tissues was significantly upregulated compared with normal tissues. In addition, we observed a significant association between HOTAIR expression and the EC grade and lymph node metastasis. Moreover, we found that a higher HOTAIR expression also correlated with the depth of myometrial invasion and lymphovascular space invasion. More importantly, patients with a higher HOTAIR expression showed significantly poorer overall survival than those with lower HOTAIR expression. |
| Pubmed ID | 24285342 |
| Year | 2014 |
| Title | The long non-coding RNA HOTAIR is upregulated in endometrial carcinoma and correlates with poor prognosis. |
External Links
| Links for HOTAIR | GenBank HGNC NONCODE |
| Links for endometrial cancer | OMIM COSMIC |