Basic Information
| LncRNA/CircRNA Name | HOTAIR |
| Synonyms | HOTAIR, HOXAS, HOXC-AS4, HOXC11-AS1, NCRNA00072 |
| Region | GRCh38_12:53962308-53974956 |
| Ensemble | ENSG00000228630 |
| Refseq | NR_003716 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | Gefitinib | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | lung adenocarcinoma |
| ICD-0-3 | C34 |
| Methods | qPCR, Western blot, in vitro knockdown, RNAi |
| Sample | cell lines (PC9, RPC9) |
| Expression Pattern | up-regulated |
| Function Description | HOTAIR silencing resulted in the upregulation of B cell lymphoma 2-associated X protein (Bax), Caspase-3 and transforming growth factor a (TGF-a) and downregulation of EGFR and B cell lymphoma 2 (Bcl-2) levels. HOTAIR normally prevents the activation of Bax/Caspase-3 while inducing TGF-a/EGFR signaling. |
| Pubmed ID | 29467862 |
| Year | 2017 |
| Title | Lentivirus-mediated silencing of HOTAIR lncRNA restores gefitinib sensitivity by activating Bax/Caspase-3 and suppressing TGF-a/EGFR signaling in lung adenocarcinoma. |
External Links
| Links for HOTAIR | GenBank HGNC NONCODE |
| Links for lung adenocarcinoma | OMIM COSMIC |