Basic Information
| LncRNA/CircRNA Name | HOTAIR |
| Synonyms | HOTAIR, HOXAS, HOXC-AS4, HOXC11-AS1, NCRNA00072 |
| Region | GRCh38_12:53962308-53974956 |
| Ensemble | ENSG00000228630 |
| Refseq | NR_003716 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric adenocarcinoma |
| ICD-0-3 | C16 |
| Methods | qPCR etc. |
| Sample | gastric adenocarcinoma tissues |
| Expression Pattern | up-regulated |
| Function Description | Here, we found aberrant up-regulation of HOTAIR in gastric adenocarcinoma samples compared with normal adjacent gastric epithelium tissues. Besides, we found that the aberrant expression of HOTAIR was associated with TNM staging and lymph node metastasis of gastric tumors. Here, a potential cooperative expression between HOTAIR SUZ12 genes in gastric adenocarcinoma tissues is deduced. This result suggests a role for HOTAIR long noncoding RNA in gastric cancer progression. |
| Pubmed ID | 23888369 |
| Year | 2013 |
| Title | Up-regulation of HOTAIR long non-coding RNA in human gastric adenocarcinoma tissues. |
External Links
| Links for HOTAIR | GenBank HGNC NONCODE |
| Links for gastric adenocarcinoma | OMIM COSMIC |