Basic Information
| LncRNA/CircRNA Name | HOTAIR |
| Synonyms | HOTAIR, HOXAS, HOXC-AS4, HOXC11-AS1, NCRNA00072 |
| Region | GRCh38_12:53962308-53974956 |
| Ensemble | ENSG00000228630 |
| Refseq | NR_003716 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | liver cancer |
| ICD-0-3 | C22.0 |
| Methods | qPCR, RNAi, Western blot, RIP etc. |
| Sample | liver cancer tissues, cell lines (hLCSC, pGFP-V-RS, pCMV6-A-GFP, pGFP-V-RS-HOTAOR, pCMV6-AGFP-HOTAIR and pcDNA3.1-STED2) |
| Expression Pattern | up-regulated |
| Function Description | We demonstrate HOTAIR promotes human liver cancer stem cell malignant growth through downregulation of SETD2. Mechanistically, HOTAIR reduces the recuritment of the CREB, P300, RNA polII onto the SETD2 promoter region that inhibits SETD2 expression and its phosphorylation. Thereby, the SETD2 binding capacity to substrate histone H3 is weakened, triggering a reduction of trimethylation on histone H3 thirty-sixth lysine, and thereby the H3K36me3-hMSH2-hMSH6-SKP2 complex is also decreased |
| Pubmed ID | 26172293 |
| Year | 2015 |
| Title | LncRNA HOTAIR promotes human liver cancer stem cell malignant growth through downregulation of SETD2 |
External Links
| Links for HOTAIR | GenBank HGNC NONCODE |
| Links for liver cancer | OMIM COSMIC |