Basic Information
| LncRNA/CircRNA Name | HOTAIR |
| Synonyms | HOTAIR, HOXAS, HOXC-AS4, HOXC11-AS1, NCRNA00072 |
| Region | GRCh38_12:53962308-53974956 |
| Ensemble | ENSG00000228630 |
| Refseq | NR_003716 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastrointestinal stromal tumor |
| ICD-0-3 | C16 |
| Methods | qPCR, RNAi, Western blot, RIP, Cell proliferation assay etc. |
| Sample | cell lines (GIST-T1, GIST882) |
| Expression Pattern | up-regulated |
| Function Description | The expression of HOTAIR was found to be higher in surgically resected high-risk GISTs than that in low- and intermediate-risk GISTs. Using GIST-T1 and GIST882 cells, we demonstrated that HOTAIR repressed apoptosis, was associated with cell cycle progression, and controlled the invasion and migration of GIST cells. We observed that HOTAIR induced PCDH10 methylation in a SUZ12-dependent manner. |
| Pubmed ID | 27659532 |
| Year | 2016 |
| Title | Promoter methylation of PCDH10 by HOTAIR regulates the progression of gastrointestinal stromal tumors. |
External Links
| Links for HOTAIR | GenBank HGNC NONCODE |
| Links for gastrointestinal stromal tumor | OMIM COSMIC |