Basic Information
| LncRNA/CircRNA Name | HOTAIR |
| Synonyms | HOTAIR, HOXAS, HOXC-AS4, HOXC11-AS1, NCRNA00072 |
| Region | GRCh38_12:53962308-53974956 |
| Ensemble | ENSG00000228630 |
| Refseq | NR_003716 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gallbladder cancer |
| ICD-0-3 | C23.9 |
| Methods | qPCR, Northern blot, RIP, in vitro knockdown etc. |
| Sample | gallbladder cancer tissues, cell lines (GBC-SD, SGC-996,NOZ, EH-GB2 etc.) |
| Expression Pattern | up-regulated |
| Function Description | The HOTAIR transcripts were expressed at higher levels in the tumor tissues compared with adjacent normal tissues, indicating that HOTAIR was frequently up-regulated in GBC.A positive correlation between c-Myc and HOTAIR mRNA levels was observed in gallbladder cancer tissues. HOTAIR is a c-Myc-activated driver of malignancy, which acts in part through repression of miRNA-130a. |
| Pubmed ID | 24953832 |
| Year | 2014 |
| Title | Long non-coding RNA HOTAIR, a c-Myc activated driver of malignancy, negatively regulates miRNA-130a in gallbladder cancer. |
External Links
| Links for HOTAIR | GenBank HGNC NONCODE |
| Links for gallbladder cancer | OMIM COSMIC |