Basic Information
| LncRNA/CircRNA Name | HOTAIR |
| Synonyms | HOTAIR, HOXAS, HOXC-AS4, HOXC11-AS1, NCRNA00072 |
| Region | GRCh38_12:53962308-53974956 |
| Ensemble | ENSG00000228630 |
| Refseq | NR_003716 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR, ChIP, Luciferase reporter assay etc. |
| Sample | primary breast tumor tissues, cell lines (MCF-7, T47D, BT474, MDA-MB-468, MDA-MB-231, ZR-75-1 etc.) |
| Expression Pattern | up-regulated |
| Function Description | We show that expression of HOTAIR is regulated by B-catenin through a LEF1/TCF4-binding site. The dual treatment blocks nuclear expression of B-catenin and prevents its recruitment to the HOTAIR promoter. Consistently, forced expression of B-catenin rescued HOTAIR expression and cell viability in the presence of both drugs. Upregulation of HOTAIR is associated with TNBC in cell lines and a cohort of primary tumors. |
| Pubmed ID | 25883211 |
| Year | 2015 |
| Title | Combined inhibition of EGFR and c-ABL suppresses the growth of triple-negative breast cancer growth through inhibition of HOTAIR. |
External Links
| Links for HOTAIR | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |